The Brazilian Institute ALLERGISA Pesquisa Dermatológica-cosmética LTDA (Reference company in clinical research in Brazil) carried out a dermatological evaluation on the product BATP® Biologic Active Tissue Paper. The study has been conducted by the Research Center of ALLERGISA on 55 people in August 2017 with positive results.
BATP® into contact to relevant eyes’ areas such as cornea, iris and conjunctiva has not revealed any symptoms of chemosis and congestion, it has been classified as NOT IRRITANT to eyes.
BATP® into contact to skin has not revealed any episodes of erythema and/or edema and it has been classified as NOT IRRITANT to skin. Furthermore, toilet paper treated with BATP® has obtained the certification as dermatologically tested product.
BATP® into contact to human vaginal epithelial cells in culture through MTT test has resulted well tolerated by the vaginal epithelial cells and classified as NOT IRRITANT to human vaginal mucosae or other epithelial tissues.
This model uses dendritic cells to determine if a test chemical can induce marker expression. BATP® into contact to dendritic cells does not induce any immunological response and subsequently it does not have any pro-sensitization potential.
The toxicology Expert Assessment including bibliographical references performed by Professor Intorre of Pharmacology and Toxicology Department – University of Pisa, confers to BATP® a safety profile. It has resulted non-toxic, non- harmful, non-irritant for the skin, eyes and human vaginal epithelium and mucosae and does not show any stimulating potential on the immune cellular response.
In Challenge Test performed by SGS Institute - Life Science Services, BATP® resulted very active in contrasting the pathogen microbial growth, as Pseudomonas Aeruginosa, Clostridium Sporogenes, Enterococcus Fecalis, Escherichia Coli, Salmonella and Staphilococcus Aureus.
Through an olfactometric sensorial analysis realized with PCA (Principal Component Analysis) has been verified that BATP® is very efficient in reducing 73% of malodors emissions produced by an absorbent substrate soaked with biological urine and incubated 12 hours at 37°C, conditions that simulated an incontinence issue.
The activity of microorganisms of BATP® has been certified as beneficial to humans and environment by INIFAP Institute (Istituto Nacional de Investigaciones Agricolas, Forestales y Pecuarias- Centro Nacional de Recursos Genéticos Microbianos – Mexico). The certification attests the efficiency of the spores in the inhibition of the pathogens bacteria growth, particularly of the Salmonella and the safety of the product itself.
Salud Secretaria de Salud, Ministry of Health, of the government of Mexican United States and Cofepris, Comisión Federal para la Protección contra Riesgos Sanitarios, Federl Commission against Health Risks, have authorised the use of BATP® applied to tissue paper without restrictions.